Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM)

Talk Code: 
KJ Mason
Mason KJ 1, Jordan KP 1, Achana F 2, Bailey J 1, Chen Y 1,3, Frisher M 4, Heron N 1,5, Huntley AL 6, Mallen CD 1, Mamas MA 7, Marshall M 1, Png ME 2, Tatton S 1, White S 4, Edwards JJ 1
Author institutions: 
1. Primary Care Centre Versus Arthritis, School of Medicine, Keele University, Keele, UK 2. Nuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK 3. Academy of Pharmacy, Xi'an Jiaotong - Liverpool University, Suzhou, China 4. School of Pharmacy and Bioengineering, Keele University, Keele, UK 5. Centre for Public Health, Queen’s University Belfast, Belfast UK 6. Centre for Academic Primary Care, Bristol Medical School, Bristol University, Bristol, UK 7. Keele Cardiovascular Research Group, Centre for Prognosis Research, Keele University, Keele, UK

Background: There is evidence that painful musculoskeletal conditions are associated with increased risk of cardiovascular disease, but less is known about whether this impacts on prognosis of cardiovascular disease. The aim was to determine whether patients with painful musculoskeletal conditions have poorer prognosis following acute coronary syndrome (ACS) or cerebrovascular accident (CVA).


The Approach: Data were obtained from national primary care records (Clinical Practice Research Datalink; CPRD) with linkage to hospitalisation and mortality records. Patients aged >45 years with incident ACS/CVA recorded in primary care and a hospital admission within ±30 days were included. Patients were stratified by consultations in primary care for painful musculoskeletal conditions (by severity and by conditions) in the 24 months prior to ACS/CVA. Severe musculoskeletal pain was defined as prescription of strong analgesia or referral in the 6 months before ACS/CVA.

Outcomes included short-term (length of stay; readmission and mortality within 30 days of discharge), management (procedures during admission; prescriptions in the 3 months post-admission) and long-term (further ACS/CVA or mortality >30 days post-discharge).

Findings: There were 171,670 patients with incident ACS (median age 70 years; 36% female) and 138,512 with incident CVA (median age 76 years; 49% female); 30% of patients consulted for musculoskeletal pain prior to ACS/CVA. Patients with musculoskeletal pain were not at increased risk of worse outcomes after ACS/CVA compared to those without pain after adjustment for socio-demographics and comorbidity. Patients with severe musculoskeletal pain or inflammatory condition were more likely to receive a procedure for ACS, and prescriptions for ACS and CVA management.

Implications: Whilst this study is reassuring given the high prevalence and disabling nature of musculoskeletal conditions, it has highlighted the complexity of patients with severe musculoskeletal pain and new onset ACS and CVA including their burden of cardiovascular risk and prognostic factors.



Funding acknowledgement: 
This project was funded by the Nuffield Foundation (OBF/43974). KJM, KPJ and CDM are also supported by matched funding awarded to the NIHR National Institute for Health Research (NIHR) Applied Research Collaboration (West Midlands). CDM is also funded by the National Institute for Health Research (NIHR) School for Primary Care Research. The study was approved by the CPRD Independent Scientific Advisory Committee (ref 20_000105).