Do patients ever do what we ask them to? Patient performance and persistence in the tasmin-sr blood pressure self-management tri

Talk Code: 
Claire Schwartz
C Schwartz, A Seyed-Safi, M S Haque, E Bray, S Greenfield, R Hobbs, P Little, J Mant, B Williams, R McManus
Author institutions: 
Please see funding acknowledgement box as to many to fit here.


Self-management of hypertension has the potential to reduce and control blood pressure (BP) above that of clinic monitoring. However it relies on patients accurately reporting their BP measurements and following an approved management protocol, which may be affected if patients have co-morbidities. This study reports on the performance of high-risk patients according to the protocol set out by the TASMIN-SR trial and assesses how successfully patients reported their readings and adhered to the recommendations.


The TASMIN-SR self-management intervention involved patients with above target clinic BP, and stroke, diabetes, CHD or CKD, self-monitoring their BP for the first week of every month followed by implementation of an individualised self-titration schedule. 276 patients were randomised to the intervention and 226 (80%) successfully completed 2 or 3 training sessions. Patients were followed up for 12 months and during this time submitted written records of home BP readings, and details of any medication changes made, on a monthly basis. BP readings were downloaded from each patient’s monitor at 6 and 12 month follow-up clinics and these were compared to those submitted along with an assessment of protocol fidelity.


Of 226 patients who were successfully trained, 174 (77%) completed self-management. 10,038/11,684 (85.9% (95% CI, 85.3 – 86.5) of all readings submitted were reported accurately, when compared to the readings downloaded from the monitor, and 164 patients (95%) reported their readings with at least 80% accuracy. There was an average error rate of 6.7% per patient and the only characteristic affecting this was age, under 65 years compared to those above (4.5%, (95% CI 3.2 – 5.6) vs 7.7%, (95% CI 6.4 – 9.0), p<0.005). In terms of protocol fidelity, 1811 (98%) of submitted records were sufficient to make a decision on whether a medication change was necessary according to the algorithm. Patients made 58.6% (370/631) of suggested medication changes, equating to 2.1/3.6 changes per patient. Baseline mean systolic BP for patients who completed the training was 143.1mmHg. Mean 12 month systolic BP was 120.9mmHg for patients who made all recommended changes, and 131.2mmHg for patients who did not make any of the recommended changes, resulting in an overall mean SBP of 126.1mmHg.


In conclusion the majority of higher risk patients with hypertension successfully monitored and reported their home BP readings and persisted with the protocol over the study resulting in significantly lower BP.

Submitted by: 
Claire Schwartz
Funding acknowledgement: 
Independent research funded by the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research Programme (Grant Reference Number RP-PG 0606-1153). On behalf of the TASMINSR Investigators (to be added to the end of the co-authors) Author Institutions University of Oxford, Oxford, United Kingdom (Schwartz, Hobbs, McManus) University of Cambridge, Cambridge, United Kingdom (Seyed-Safi and Mant) University of Birmingham, Birmingham, United Kingdom (Haque and Greenfield) University of Central Lancashire, Preston, Lancashire, United Kingdom (Bray) University of Southampton, Southampton, United Kingdom (Little) University College London, London, United Kingdom (Williams)